20060101
A
61 K 39 395 A 20060101
A
61 P 25 00 A 20060101
A
61 P 29 00 A 20060101
A
61 P 43 00 A 20060101
C
07 K 16 28 A 20060101
C
12 N 15 13 A OA 1/2010/000275 20090204 US 61/025,995 20080204 LAY LINE GENOMICS S.P.A.
Via Prospero Colonna, 32 IT
IT BENIGNI Fabio
via Olgettina 58 IT
D'AMBROSIO, Daniele
via Olgettina 58 IT
CABINET ISIS CONSEILS (SCP)
B.P. 15424, YAOUNDE CM
Anti - TRKA antibodies and derivatives thereof 20190710 018848 20290204 EP PCT/EP09/051285 20090204 IB WO/09/098238 20090813 20090204 20190710 20190903 BR Brevet PCT

<p>An anti-TrkA antibody is provided that comprises: a) a variable heavy chain comprising a sequence selected fromany of BXhVH1, BXhVH2, BXhVH3, BXhVH4, BXhVH5, or HuVHWOv as shown in Figure (1a); or from variants of any of said sequences and/or b) a variable light chain comprising a sequence selected from any of BXhVL1, BXhVL2, BXhVL3, BXhVL4, BXhVL5, BXhVL6, BXhVL7 or BXhVL8; as shown in Figure (1b), or from variants of any of said sequences.TrkA-binding derivatives are also provided. Antibodies or derivatives of the present invention are useful in a number of therapies, including pain therapy.</p>