Type de la demande
BR Brevet
Sous-type de la demande
BR Brevet PCT
(10) Numéro et date d'enregistrement
018848 2019.07.10
Satut
529
(180) Date d'expiration
2029.02.04
(20) Numéro et date de dépot
OA 1/2010/000275 2009.02.04
(40) Numéro et date de publication
(86) PCT Numéro et date de dépoôt
(87) PCT Numéro et date de publication
(85) Date d'entrée en phase Nationale
(30) Détails de la priorité
US 61/025,995
2008.02.04
(51) CIB
(71/73) Déposant
(FR) LAY LINE GENOMICS S.P.A. : Via Prospero Colonna, 32
(72) Inventeur
(FR) BENIGNI Fabio : via Olgettina 58
(FR) D'AMBROSIO, Daniele : via Olgettina 58
(74) Nom du représentant
(FR) CABINET ISIS CONSEILS (SCP) : B.P. 15424, YAOUNDE
(54) intituler
(FR) Anti - TRKA antibodies and derivatives thereof
(57) Abrégé
(FR)
An anti-TrkA antibody is provided that comprises: a) a variable heavy chain comprising a sequence selected fromany of BXhVH1, BXhVH2, BXhVH3, BXhVH4, BXhVH5, or HuVHWOv as shown in Figure (1a); or from variants of any of said sequences and/or b) a variable light chain comprising a sequence selected from any of BXhVL1, BXhVL2, BXhVL3, BXhVL4, BXhVL5, BXhVL6, BXhVL7 or BXhVL8; as shown in Figure (1b), or from variants of any of said sequences.TrkA-binding derivatives are also provided. Antibodies or derivatives of the present invention are useful in a number of therapies, including pain therapy.
(58) Citations