BOPI 09 BR/2024 REPERTOIRE NUMERIQUE 16 C12Q 1/6897 (2019.01) ; G01N 33/533 (2019.01) (21) 1202400086 - PCT/RU2022/050279 (22) 06/09/2022 (30) RU n° 2021126254 du 07/09/2021 (54) Inducible promoter, vector and host cell based thereon. (72) MOROZOV, Dmitry Valentinovich (RU); KONONOV, Aleksey Vladimirovich (RU); SOLOVYEV, Valéry Vladimirovich (RU); ZHIRIAKOVA, Mariia Vladimirovna (RU); GORDEEV, Aleksandr Andreevich (RU) et PUCHKOVA, Mariia Yurievna (RU) (73) JOINT STOCK COMPANY ‘‘BIOCAD’’, 198515, Saint Petersburg, vn. ter. g. poselok Strelna, ul. Svyazi, d. 38, str. 1, pomeshch. 89, Russian Federation (RU) (74) Cabinet ISIS CONSEILS (SCP), Bastos, face de l'Agence Turque de Coopération et de Coordination, B.P. 15067, YAOUNDE (CM). (57) The present invention relates to the fields of biotechnology and molecular biology, in particular to a universal inducible promoter, vector and host cell based thereon, as well as to a method for producing said host cell. The proposed inventions make it possible to analyze the activity of a target protein, for example, a receptor ligand, for example, a cytokine. Fig. 2 ________________________________________ (11) 21635 Consulter le mémoire (51) C07K 16/28 (2019.01); C07K 16/46 (2019.01); C12N 15/13 (2019.01); C12N 15/63 (2019.01) ; C12P 21/08 (2019.01) (21) 1202400088 - PCT/RU2022/050281 (22) 07/09/2022 (30) RU n° 2021126369 du 08/09/2021 (54) Bispecific Antibody Comprising A Heterodimer Based On Mhc Proteins. (72) MOROZOV, Dmitry Valentinovich (RU); IAKOVLEV, Pavel Andreevich (RU); LEGOTSKII, Sergei Aleksandrovich (RU); NAZARENKO, Olga Viktorovna (RU); DANILOV, Maksim Andreevich (RU); BARANOVSKAIA, Marianna Dmitrievna (RU); POLIAKOV, Dmitrii Nikolaevich (RU); VALIAKHMETOVA, Elvira Raisovna (RU); TOPORKOVA, Kseniia Aleksandrovna (RU); MATIUKHINA, Natalia Mikhailovna (RU); KRAT, Sergei Mikhailovich (RU) et GURINA, Natalia Nikolaevna (RU) (73) Joint Stock Company ‘‘Biocad’’, 198515, Saint Petersburg, vn. ter. g. poselok strelna, ul. Svyazi, d. 38, str. 1, pomeshch. 89, Russian Federation (RU) (74) Cabinet ISIS CONSEILS (SCP), Bastos, face de l'Agence Turque de Coopération et de Coordination, BP 15067, YAOUNDE (CM). (57) The present invention relates to the field of biotechnology, specifically to bivalent bispecific chimeric antibodies that include a heterodimer based on the membrane-proximal domains of MHC (major histocompatibility complex) or MHClike proteins (CD1 (cluster of differentiation 1) or HFE (hemochromatosis protein)), as well as to a technique for producing said bispecific antibodies. The invention further relates to a nucleic acid encoding said bispecific antibody, an expression vector, a host cell for producing said bivalent
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